Article
Volumetric analysis of the terminal ductal lobular unit architecture and cell phenotypes in the human breast.
Cell reports - 22 Oct 2024
Paavolainen Oona, Peurla Markus, Koskinen Leena M, Pohjankukka Jonna, Saberi Kamyab, Tammelin Ella, Sulander Suvi-Riitta, Valkonen Masi, Mourao Larissa, Boström Pia, Brück Nina, Ruusuvuori Pekka, Scheele Colinda L G J, Hartiala Pauliina, Peuhu Emilia
Abstract excerpt
The major lactiferous ducts of the human breast branch out and end at terminal ductal lobular units (TDLUs). Despite their functional and clinical importance, the three-dimensional (3D) architecture of TDLUs has remained undetermined. Our quantitative and volumetric imaging of healthy human breast tissue demonstrates that highly branched TDLUs, which exhibit increased proliferation, are uncommon in the resting...
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