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Article

Negative regulation of TIM-3 expression in AML cell line (HL-60) using miR-330-5p

24 Jun 2016

Abstract excerpt

BACKGROUND: Uncontrolled proliferation and accumulation of leukaemic stem cells (LSCs) in bone marrow leads to acute myeloma leukaemia (AML). T cell immunoglobulin and mucine domain (TIM)-3 is a specific surface marker for LSCs and is highly expressed on LSCs compared with normal bone marrow cells, haematopoietic stem cells. Studies have indicated that microRNAs can affect AML progression through targeting...

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PMID: 27341144
DOI: 10.1080/09674845.2016.1194564

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