Article
NPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemia.
Oncoimmunology - 1 Jan 2022
Kuželová Kateřina, Brodská Barbora, Marková Jana, Petráčková Martina, Schetelig Johannes, Ransdorfová Šárka, Gašová Zdenka, Šálek Cyril
Abstract excerpt
The immune system is important for elimination of residual leukemic cells during acute myeloid leukemia (AML) therapy. Anti-leukemia immune response can be inhibited by various mechanisms leading to immune evasion and disease relapse. Selected markers of immune escape were analyzed on AML cells from leukapheresis at diagnosis (N = 53). Hierarchical clustering of AML immunophenotypes yielded distinct genetic...
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