Article

Therapeutic Targeting of TIM-4-L With Engineered T Cells for Acute Myeloid Leukemia

2023-10-04

Abstract excerpt

Disruption of the lipid asymmetric bilayer is a common feature observed in cancer cells. We utilized the natural immune receptor TIM-4 to interrogate for loss of plasma membrane phospholipid polarity in primary acute myelogenous leukemia (AML) samples. We performed FACs analysis in 33 patients and correlated TIM-4-L expression frequency and intensity with molecular disease characteristics. In normal tissues, TIM-4...

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Literature Corpus work: 3187fbcb-293f-5ff0-b830-d8ef12fb715e
DOI: 10.1101/2023.10.03.560752

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