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Article

T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells

25 Jun 2016

Abstract excerpt

In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogeneous population described in inflammatory and infectious diseases and in numerous tumors...

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PMID: 27338100
DOI: 10.1182/blood-2015-08-662783

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