Article
On the origin of myeloid-derived suppressor cells.
Oncotarget - 10 Jan 2017
Millrud Camilla Rydberg, Bergenfelz Caroline, Leandersson Karin
Abstract excerpt
Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. In cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs). The classical definition of MDSCs as immature myeloid cells blocked from differentiating has...
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