Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relationship between genetic polymorphisms of drug efflux transporter MDR1 (ABCB1) and response to losartan in hypertension patients.

European review for medical and pharmacological sciences - 1 Jun 2016

Göktaş M T, Pepedil F, Karaca Ö, Kalkışım S, Cevik L, Gumus E, Guven G S, Babaoglu M O, Bozkurt A, Yasar U

Abstract excerpt

OBJECTIVE: Losartan is a selective angiotensin II receptor type 1 blocker and a substrate of drug efflux transporter MDR1 (ABCB1). MDR1 shows inter-individual variations due to genetic polymorphisms. C3435T, G2677T and C1236T polymorphic alleles of the MDR1 gene encoding the transporter have been shown to alter the transport, bioavailability and efficacy of certain drugs. The purpose of this study was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to ABCB1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Haplotypes

Share to Hypertension

Share to Losartan

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 27338075

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relationship between genetic polymorphisms of drug efflux transporter MDR1 (ABCB1) and response to losartan in hypertension patients.PMID 27338075Read ↗

Investigation of MDR1 Gene Polymorphism and Losartan Plasma Concentration in Patients Undergoing Hypertensive Episodes While under Losartan TreatmentSemantic proximity Read ↗

Investigation of MDR1 Gene Polymorphism and Losartan Plasma Concentration in Patients Undergoing Hypertensive Episodes While under Losartan TreatmentSemantic proximity Read ↗

Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients.Semantic proximity Read ↗

MDR1 gene polymorphisms and clinical relevance.Semantic proximity Read ↗

Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals.Semantic proximity Read ↗

Pharmacogenetics of drug transporters and its impact on the pharmacotherapy.Semantic proximity Read ↗

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevanceSemantic proximity Read ↗

Pharmacogenetic study of ACE, AGT, CYP11B1, CYP11B2 and eNOS gene variants in hypertensive patients from Faisalabad, Pakistan.Semantic proximity Read ↗

Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.Semantic proximity Read ↗

Angiotensin II receptor polymorphisms in hypertension. Pharmacogenomic considerations.Semantic proximity Read ↗

[Individual sensitivity to antihypertensive drugs: genetic aspects].Semantic proximity Read ↗

Do MDR1 and SLCO1B1 polymorphisms influence the therapeutic response to atorvastatin? A study on a cohort of Egyptian patients with hypercholesterolemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.