Article
Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients.
Molecular biology reports - 29 Mar 2024
da Cunha Agostini Lívia, de Paula Waléria, Melo André Sacramento, Silva Nayara Nascimento Toledo, Faria Lopes Ana Cláudia, de Almeida Belo Vanessa, Coura-Vital Wendel, de Medeiros Teixeira Luiz Fernando, Lima Angélica Alves, da Silva Glenda Nicioli
Abstract excerpt
Arterial hypertension is characterized by systolic pressure ≥ 140 mmHg and/or diastolic pressure ≥ 90 mmHg and its treatment consists of the use of antihypertensive drugs, as losartan and hydrochlorothiazide. Blood pressure is regulated by angiotensin-converting enzyme (ACE) and polymorphisms in the ACE gene are associated to a greater predisposition to hypertension and response to treatment. The aim of this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.