Article

Investigation of MDR1 Gene Polymorphism and Losartan Plasma Concentration in Patients Undergoing Hypertensive Episodes While under Losartan Treatment

2023-09-07

Abstract excerpt

<h4>Purpose: </h4> Losartan, a drug in the angiotensin receptor blocker (ARB) family, is the substrate of the Multi Drug Resistance-1 (MDR1) drug-efflux protein encoded by the ABCB1 gene. This study seeks to investigate the MDR1 gene polymorphism and losartan concentration in order to identify drug resistance in patients presenting to the emergency department (ED) with a hypertensive episode while having losartan...

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Literature Corpus work: 84eb27ac-47c9-5bdf-ac5a-a42359c6faa7
DOI: 10.21203/rs.3.rs-3307354/v1

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