Article
CYP3A5 as a candidate gene for hypertension: no support from an unselected indigenous West African population.
Journal of human hypertension - 1 Dec 2016
Fisher D L, Plange-Rhule J, Moreton M, Eastwood J B, Kerry S M, Micah F, Johnston A, Cappuccio F P, MacPhee I A M
Abstract excerpt
CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) expression stimulates the sodium retentive actions of the mineralocorticoid receptor causative of hypertension, probably by means of its ability to substantially increase the level of 6β-hydroxylase activity. Most Black individuals are functional CYP3A5 expressers, and this is a candidate gene for the high incidence of hypertension in Black...
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