Article
Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy.
Biochemical and biophysical research communications - 2 Jul 2010
Coto Eliecer, Tavira Beatriz, Marín Rafael, Ortega Francisco, López-Larrea Carlos, Ruiz-Ortega Marta, Ortiz Alberto, Díaz Marta, Corao Ana I, Alonso Belén, Alvarez Victoria
Abstract excerpt
An intronic single nucleotide polymorphism (SNP) in the CYP3A5 gene (CYP3A5*3; SNP rs776746) affects RNA splicing and enzymatic activity. The CYP3A5*3 frequency increased with distance from the equator and natural selection has been proposed to explain the worldwide distribution of this allele. CYP3A activity has been related with the risk for hypertension in pregnancy, a major cause of morbidity and mortality...
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