Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Sept 2003

Givens Raymond C, Lin Yvonne S, Dowling Amy L S, Thummel Kenneth E, Lamba Jatinder K, Schuetz Erin G, Stewart Paul W, Watkins Paul B

Abstract excerpt

A single-nucleotide polymorphism (A6986G) in the cytochrome p-450 3A5 (CYP3A5) gene distinguishes an expressor (*1) and a reduced-expressor (*3) allele and largely predicts CYP3A5 content in liver and intestine. CYP3A5 is the prevailing CYP3A isoform in kidney. We report that, among renal microso...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Black People
Share to Creatinine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Cytochrome P-450 Enzyme System

Share to Hispanic or Latino

Share to Microsomes

Share to Oxidoreductases, N-Demethylating

Source

Identifiers

PMID: 12754175
DOI: 10.1152/japplphysiol.00322.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12754175-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.PMID 12754175Read ↗

CYP3A5 polymorphism, amlodipine and hypertension.Semantic proximity Read ↗

CYP3A5 genotype is associated with elevated blood pressure.Semantic proximity Read ↗

CYP3A5 genotype-phenotype analysis in the human kidney reveals a strong site-specific expression of CYP3A5 in the proximal tubule in carriers of the CYP3A5*1 allele.Semantic proximity Read ↗

Association of CYP3A5 genotypes with blood pressure and renal function in African families.Semantic proximity Read ↗

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.Semantic proximity Read ↗

CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men.Semantic proximity Read ↗

CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease.Semantic proximity Read ↗

Associations Between CYP3A5 (c.6986A>G) Gene Polymorphism and Kidney Impairment in Hypertensive Adults Without Cystatin C Elevation.Semantic proximity Read ↗

CYP3A variation and the evolution of salt-sensitivity variants.Semantic proximity Read ↗

Association between CYP3A5 polymorphisms and blood pressure in kidney transplant recipients receiving calcineurin inhibitors.Semantic proximity Read ↗

Association between the CYP3A5 genotype and blood pressure.Semantic proximity Read ↗

Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.