Article
Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Sept 2016
Dimberg Jan, Skarstedt Marita, Slind Olsen Renate, Andersson Roland E, Matussek Andreas
Abstract excerpt
The DNA repair genes XRCC1 and XRCC6 have been proposed to participate in the pathological process of cancer by modulating the DNA repair capacity. This study evaluated the susceptibility of the single-nucleotide polymorphisms (SNPs) XRCC1 (rs25487, G > A) and XRCC6 (rs2267437, C > G) to colorectal cancer (CRC) and their association with clinical parameters in Swedish patients with CRC. Using the TaqMan system,...
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