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Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration

21 Jun 2016

Abstract excerpt

The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described in adult ovaries after Foxl2 ablation. Dmrt1 plays a similar role in postnatal testes, but the mechanism of adult testis maintenance remains mostly unknown. Sox9 and Sox8 are required for postnatal male fertility, but their role in the...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 27328324
DOI: 10.7554/elife.15635

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Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degenerationPMID 27328324Read ↗

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Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex DeterminationSemantic proximity Read ↗

Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversalsSemantic proximity Read ↗

DMRT1 is a testis-determining gene in rabbits and is also essential for female fertilitySemantic proximity Read ↗

Sox8 is a critical regulator of adult Sertoli cell function and male fertility.Semantic proximity Read ↗

SOX Genes and Their Role in Disorders of Sex DevelopmentSemantic proximity Read ↗

<i>DMRT1</i> is a testis determining gene in rabbits and is also essential for female fertilitySemantic proximity Read ↗

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