Article

DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility

2023-10-17

Abstract excerpt

DMRT1 is the testis-determining factor in several species of vertebrates, but its involvement in mammalian testes differentiation, where SRY is the testis-determining gene, remains ambiguous. So far, DMRT1 loss-of-function has been described in two mammalian species and induces different phenotypes: Disorders of Sex Development (46, XY DSD) in men and male infertility in mice. We thus abolished DMRT1 expression by...

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Literature Corpus work: 53720cae-cd2f-5844-91c2-5d04edda7c63
DOI: 10.7554/elife.89284.3

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