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Article

Sox8 is a critical regulator of adult Sertoli cell function and male fertility.

Developmental biology - 15 Apr 2008

O'Bryan Moira K, Takada Shuji, Kennedy Claire L, Scott Greg, Harada Shun-ichi, Ray Manas K, Dai Qunsheng, Wilhelm Dagmar, de Kretser David M, Eddy E Mitch, Koopman Peter, Mishina Yuji

Abstract excerpt

Sox8 encodes a high-mobility group transcription factor that is widely expressed during development. Sox8, -9 and -10 form group E of the Sox gene family which has been implicated in several human developmental disorders. In contrast to other SoxE genes, the role of Sox8 is unclear and Sox8 mouse mutants reportedly showed only idiopathic weight loss and reduced bone density. The careful analysis of our Sox8 null...

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Source

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Identifiers

PMID: 18342849
DOI: 10.1016/j.ydbio.2008.01.042
PMCID: PMC2375044

Genes

SOX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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