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Article

The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming

18 May 2021

Abstract excerpt

Mammalian sexual development commences when fetal bipotential progenitor cells adopt male Sertoli (in XY) or female granulosa (in XX) gonadal cell fates. Differentiation of these cells involves extensive divergence in chromatin state and gene expression, reflecting distinct roles in sexual differentiation and gametogenesis. Surprisingly, differentiated gonadal cell fates require active maintenance through...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 34096593
DOI: 10.1093/nar/gkab448

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