Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex Determination

doi:10.3390/genes12040486

Article

Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex Determination

26 Mar 2021

Abstract excerpt

Sex determination occurs early during embryogenesis among vertebrates. It involves the differentiation of the bipotential gonad to ovaries or testes by a fascinating diversity of molecular switches. In most mammals, the switch is SRY (sex determining region Y); in other vertebrates it could be one of a variety of genes including Dmrt1 or dmy. Downstream of the switch gene, SOX9 upregulation is a central event in...

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