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Article

Sexual cell-fate reprogramming in the ovary by DMRT1.

Current biology : CB - 16 Mar 2015

Lindeman Robin E, Gearhart Micah D, Minkina Anna, Krentz Anthony D, Bardwell Vivian J, Zarkower David

Abstract excerpt

Transcription factors related to the insect sex-determination gene doublesex (DMRT proteins) control sex determination and/or sexual differentiation in diverse metazoans and are implicated in transitions between sex-determining mechanisms during vertebrate evolution [1]. In mice, Dmrt1 is required for male gonadal differentiation in somatic cells and germ cells [2-4]. DMRT1 also maintains male gonadal sex: its...

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Identifiers

PMID: 25683803
DOI: 10.1016/j.cub.2015.01.034
PMCID: PMC4366330

Genes

DMRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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