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Article

SOX Genes and Their Role in Disorders of Sex Development

1 Jan 2022

Abstract excerpt

SOX genesare master regulatory genes controlling development and are fundamental to the establishment of sex determination in a multitude of organisms. The discovery of the master sex-determining gene SRY in 1990 was pivotal for the understanding of how testis development is initiated in mammals. With this discovery, an entire family of SOX factors were uncovered that play crucial roles in cell fate decisions...

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PMID: 35760052
DOI: 10.1159/000524453

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