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Article

Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals

25 May 2020

Abstract excerpt

In mammals, testicular differentiation is initiated by transcription factors SRY and SOX9 in XY gonads, and ovarian differentiation involves R-spondin1 (RSPO1) mediated activation of WNT/β-catenin signaling in XX gonads. Accordingly, the absence of RSPO1/Rspo1 in XX humans and mice leads to testicular differentiation and female-to-male sex reversal in a manner that does not requireSry or Sox9 in mice. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32450947
DOI: 10.7554/elife.53972

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Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversalsPMID 32450947Read ↗

<i>Sox8</i> and <i>Sox9</i> act redundantly for ovarian-to-testicular fate reprogramming in the absence of <i>R-spondin1</i> in mouse sex reversalsSemantic proximity Read ↗

Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex ReversalsSemantic proximity Read ↗

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Genetics of Ovarian Differentiation: <i>Rspo1</i>, a Major PlayerSemantic proximity Read ↗

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signalingSemantic proximity Read ↗

Rspo1-activated signalling molecules are sufficient to induce ovarian differentiation in XY medaka (Oryzias latipes)Semantic proximity Read ↗

SRY and the Standoff in Sex DeterminationSemantic proximity Read ↗

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degenerationSemantic proximity Read ↗

Deciphering Sex-Specific Differentiation of Human Fetal Gonads: Insight From Experimental ModelsSemantic proximity Read ↗

WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonadSemantic proximity Read ↗

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