Article
Transcript expression and genetic variability analysis of caspases in breast carcinomas suggests CASP9 as the most interesting target.
Clinical chemistry and laboratory medicine - 1 Jan 2017
Brynychova Veronika, Hlavac Viktor, Ehrlichova Marie, Vaclavikova Radka, Nemcova-Furstova Vlasta, Pecha Vaclav, Trnkova Marketa, Mrhalova Marcela, Kodet Roman, Vrana David, Gatek Jiri, Bendova Marie, Vernerova Zdenka, Kovar Jan, Soucek Pavel
Abstract excerpt
BACKGROUND: Apoptosis plays a critical role in cancer cell survival and tumor development. We provide a hypothesis-generating screen for further research by exploring the expression profile and genetic variability of caspases (2, 3, 7, 8, 9, and 10) in breast carcinoma patients. This study addressed isoform-specific caspase transcript expression and genetic variability in regulatory sequences of caspases 2 and 9....
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