Article
Distribution of coding apoptotic gene polymorphisms in women with extreme phenotypes of breast cancer predisposition and tolerance.
Tumori - 1 Jan 2000
Ulybina Yulia M, Kuligina Ekatherina S, Mitiushkina Nathalia V, Sherina Nathalia Y, Baholdin Dmitry V, Voskresenskiy Dmitry A, Polyakov Igor S, Togo Alexandr V, Semiglazov Vladimir F, Imyanitov Evgeny N
Abstract excerpt
AIMS AND BACKGROUND: Comparison of subjects with extreme phenotypes of cancer susceptibility and tolerance allows to detect low-penetrance gene-disease interactions with a relatively small study size. METHODS AND STUDY DESIGN: We analyzed the distribution of 19 coding apoptotic gene polymorphisms (Bid Gly10Ser; Casp2 Leu141Val; Casp5 Ala90Thr and Val318Leu; Casp7 Glu255Asp; Casp8 His302Asp; Casp9 Val28Ala,...
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