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Article

Genetic variations in drug-metabolizing enzyme CYP2C9 among major ethnic groups of Pakistani population.

Gene - 1 Jul 2020

Hizbullah, Ahmed Sagheer, Noor Mumtaz Mah, Zulfiqar Zaira, Amir Hamza Sheikh, Siraj Sami, Jelani Musharraf, Imran Imran, Khan Asifullah

Abstract excerpt

The genetic polymorphism of cytochrome P450 (CYPs)drug-metabolizing enzymes are well studied in human populations for drug safety and efficacy. CYP2C9 is a highly polymorphic CYP enzyme that oxidizing the indigenous compounds and xenobiotics. The present study was pursued to evaluate the genetic variation across the CYP2C9 gene among major groups of the Pakistani population. The CYP2C9 genomic region holding...

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Identifiers

PMID: 32276000
DOI: 10.1016/j.gene.2020.144659

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