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Article

FOXO3 is differentially required for CD8+ T-cell death during tolerance versus immunity.

Immunology and cell biology - 1 Oct 2016

Wagle Mayura V, Parish Ian A

Abstract excerpt

Peripheral tolerance mechanisms limit autoimmunity by constitutively eliminating self-reactive CD8+ T cells from the periphery in a process called deletion. Previous work has demonstrated that this deletion process is mediated by BIM-dependent apoptotic death due to transcriptional induction of the Bim gene. Currently, the transcriptional pathways responsible for Bim induction during peripheral deletion remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27323690
DOI: 10.1038/icb.2016.53

Genes

FOXO3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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