Article
PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease
8 Apr 2022
Abstract excerpt
Immunological tolerance is established and maintained by a diverse array of safeguards that work together to protect against autoimmunity. Despite the identification of numerous tolerogenic processes, the basis for cooperation among them remains poorly understood. We sought to identify synergy among several well-defined tolerance mediators that alone provide protection only from mild autoimmune symptoms in...
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