Differential cytokine withdrawal-induced death sensitivity of effector T cells derived from distinct human CD8+ memory subsets

Abstract excerpt

Abstract CD8+central memory (CM) and effector memory (EM) T-cell subsets exhibit well-established differences in proliferative and protective capacity after infectious challenge. However, their relative sensitivity to apoptosis has been largely overlooked, despite the importance of programmed cell death in regulating effector T-cell homeostasis. Here we demonstrate that primary human effector T cells derived from...

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