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Article

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein.

EMBO reports - 1 Nov 2013

Herold Marco J, Rohrbeck Leona, Lang Mathias J, Grumont Raelene, Gerondakis Steve, Tai Lin, Bouillet Philippe, Kaufmann Thomas, Strasser Andreas

Abstract excerpt

The BH3-only protein Bim is a critical initiator of apoptosis in hematopoietic cells. Bim is upregulated in response to growth factor withdrawal and in vitro studies have implicated the transcription factor Foxo3a as a critical inducer. To test the importance of this regulation in vivo, we genera...

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Identifiers

PMID: 24060902
DOI: 10.1038/embor.2013.152
PMCID: PMC3818073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24060902-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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