Article

B-cell tolerance and autoimmunity

2017-03-29

Abstract excerpt

Self-reactive B cells are tolerized at various stages of B-cell development and differentiation, including the immature B-cell stage (central tolerance) and the germinal center (GC) B-cell stage, and B-cell tolerance involves various mechanisms such as deletion, anergy, and receptor editing. Self-reactive B cells generated by random immunoglobulin variable gene rearrangements are tolerized by central tolerance and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ed36402-d387-590b-a124-ae6bc7308569
DOI: 10.12688/f1000research.10583.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

B-cell tolerance and autoimmunityDOI 10.12688/f1000research.10583.1Read

B cell tolerance and autoimmunity: Lessons from repertoiresSemantic proximity Read

Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis.Semantic proximity Read

An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cellsSemantic proximity Read

Self-Reactive B Cells in the Germinal Center ReactionSemantic proximity Read

The molecular basis of immune regulation in autoimmunity.Semantic proximity Read

Autoimmunity and Cancer—Two Sides of the Same CoinSemantic proximity Read

Activation of self-reactive B cells and autoimmune diseases.Semantic proximity Read

Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B-cell responses under strongly immunogenic conditionsSemantic proximity Read

B cell abnormalities and autoantibody production in patients with partial RAG deficiency.Semantic proximity Read

Regulation of autoreactive antibodiesSemantic proximity Read

Cellular and genetic mechanisms of self tolerance and autoimmunitySemantic proximity Read

The enemy within: keeping self-reactive T cells at bay in the periphery.Semantic proximity Read