Article
Purinergic Signaling as a Regulator of Th17 Cell Plasticity.
PloS one - 1 Jan 2016
Fernández Dominique, Flores-Santibáñez Felipe, Neira Jocelyn, Osorio-Barrios Francisco, Tejón Gabriela, Nuñez Sarah, Hidalgo Yessia, Fuenzalida Maria Jose, Meza Daniel, Ureta Gonzalo, Lladser Alvaro, Pacheco Rodrigo, Acuña-Castillo Claudio, Guixé Victoria, Quintana Francisco J, Bono Maria Rosa, Rosemblatt Mario, Sauma Daniela
Abstract excerpt
T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation. Recent evidence, supporting the notion of a functional and phenotypic instability of Th17 cells, has shown that Th17 differentiate into type 1 regulatory (Tr1) T cells...
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