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Article

A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Kaku Hiroaki, Cheng Kai Fan, Al-Abed Yousef, Rothstein Thomas L

Abstract excerpt

Immune suppression by regulatory T cells and regulatory B cells is a critical mechanism to limit excess inflammation and autoimmunity. IL-10 is considered the major mediator of B cell-induced immune suppression. We report a novel mechanism for immune suppression through adenosine generation by B cells. We identified a novel population of B cells that expresses CD73 as well as CD39, two ectoenzymes that together...

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Identifiers

PMID: 25392527
DOI: 10.4049/jimmunol.1400336
PMCID: PMC4321875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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