Article
Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells.
Clinical and experimental immunology - 1 Aug 2014
Schuler P J, Saze Z, Hong C-S, Muller L, Gillespie D G, Cheng D, Harasymczuk M, Mandapathil M, Lang S, Jackson E K, Whiteside T L
Abstract excerpt
While murine CD4(+) CD39(+) regulatory T cells (T(reg)) co-express CD73 and hydrolyze exogenous (e) adenosine triphosphate (ATP) to immunosuppressive adenosine (ADO), surface co-expression of CD73 on human circulating CD4(+) CD39(+) T(reg) is rare. Therefore, the ability of human T(reg) to produce and utilize ADO for suppression remains unclear. Using mass spectrometry, we measured nucleoside production by...
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