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Article

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation

25 May 2020

Abstract excerpt

Vaccination is a mainstay in preventive medicine, reducing morbidity and mortality from infection, largely by generating pathogen-specific neutralizing antibodies. However, standard immunization strategies are insufficient with increasing age due to immunological impediments, including defects in T follicular helper (Tfh) cells. Here, we found that Tfh generation is inversely linked to the expression of the...

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PMID: 32452837
DOI: 10.1172/jci132417

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