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Article

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation.

Journal of autoimmunity - 1 Apr 2015

Rissiek Anne, Baumann Isabell, Cuapio Angelica, Mautner Andrea, Kolster Manuela, Arck Petra C, Dodge-Khatami Ali, Mittrücker Hans-Willi, Koch-Nolte Friedrich, Haag Friedrich, Tolosa Eva

Abstract excerpt

Regulatory T cells (Tregs) use different mechanisms to exert their suppressive function, among them the conversion of ATP to adenosine initiated by the ectonucleotidase CD39. In humans, the expression of CD39 on Tregs shows a high interindividual variation, and is especially high at sites of inflammation, like the synovia of patients with arthritis. How CD39 expression is regulated, and the functional...

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PMID: 25640206
DOI: 10.1016/j.jaut.2014.12.007

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