Article
CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells.
Immunology - 1 Dec 2015
Flores-Santibáñez Felipe, Fernández Dominique, Meza Daniel, Tejón Gabriela, Vargas Leonardo, Varela-Nallar Lorena, Arredondo Sebastián, Guixé Victoria, Rosemblatt Mario, Bono María Rosa, Sauma Daniela
Abstract excerpt
The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in the presence of transforming growth factor-β (TGF-β), and hence CD73 expression is related to the acquisition of immunosuppressive potential by these cells. TGF-β is also able to induce CD73...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.