SIRT2 and lysine fatty acylation regulate the oncogenic activity of K-Ras4a

Abstract excerpt

Ras proteins play vital roles in numerous biological processes and Ras mutations are found in many human tumors. Understanding how Ras proteins are regulated is important for elucidating cell signaling pathways and identifying new targets for treating human diseases. Here we report that one of the K-Ras splice variants, K-Ras4a, is subject to lysine fatty acylation, a previously under-studied protein post-translat...

Topics

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• Cell Proliferation
• HEK293 Cells
• Mice
• Mice, Knockout
• Models, Molecular
• Mutant Proteins
• NIH 3T3 Cells
• Sirtuins

Identifiers and source

Literature Corpus work

521c0a7d-1994-5e59-86a5-61a906d45c54

DOI

10.1101/203638