Article
Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
3 Jul 2017
Abstract excerpt
Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and that inhibition of downstream components of Gln metabolism leads to a decrease in tumour growth....
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