Article
Functional Analysis of Hif1 Histone Chaperone in Saccharomyces cerevisiae.
G3 (Bethesda, Md.) - 31 May 2018
Dannah Nora S, Nabeel-Shah Syed, Kurat Christoph F, Sabatinos Sarah A, Fillingham Jeffrey
Abstract excerpt
The Hif1 protein in the yeast Saccharomyces cerevisie is an evolutionarily conserved H3/H4-specific chaperone and a subunit of the nuclear Hat1 complex that catalyzes the acetylation of newly synthesized histone H4. Hif1, as well as its human homolog NASP, has been implicated in an array of chromatin-related processes including histone H3/H4 transport, chromatin assembly and DNA repair. In this study, we...
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