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Article

The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia.

The Journal of biological chemistry - 6 Jan 2012

Zhao Huiwu, Jin Shenghao, Gewirtz Alan M

Abstract excerpt

The histone acetyltransferase TIP60 is a coregulator of transcription factors and is implicated in tumorigenesis. In this study, we explored potential regulatory relationships between TIP60 and the c-Myb oncoprotein in hematopoietic cells. We first showed that TIP60 is a c-Myb interacting protein and that the interaction is dependent on the TIP60 acetyltransferase domain and c-Myb transactivation domain. We then...

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Share to Gene Expression Regulation, Enzymologic
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histone Deacetylase 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 22110127
DOI: 10.1074/jbc.M111.279950
PMCID: PMC3256894

Genes

HDAC1
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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