Article
Tip60 is a co-activator specific for class I nuclear hormone receptors.
The Journal of biological chemistry - 14 Dec 2001
Gaughan L, Brady M E, Cook S, Neal D E, Robson C N
Abstract excerpt
The nuclear hormone receptor superfamily is composed of a group of hormone-dependent transcription factors that play prominent roles in homeostatic events in vertebrates. A prerequisite for steroid hormone receptor activity is the binding of co-activator molecules to the activation function-2 domain of the receptor. The LXXLL motif/nuclear receptor box, contained within a number of co-activator molecules,...
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