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Article

Dendritic cells in hepatitis C virus infection: key players in the IFNL3-genotype response.

World journal of gastroenterology - 21 Dec 2014

O'Connor Kate S, George Jacob, Booth David, Ahlenstiel Golo

Abstract excerpt

Recently, single nucleotide polymorphisms, in the vicinity of the interferon lambda 3 (IFNL3) gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus (HCV) infection. Since then, increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype effect. Dendritic cells (DCs) are key to the host immune response in HCV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25548481
DOI: 10.3748/wjg.v20.i47.17830
PMCID: PMC4273133

Genes

IFNL3

Provenance

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