Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting.

PloS one - 1 Jan 2015

Wiegand Steffen B, Heidrich Benjamin, Susser Simone, Rogalska-Taranta Magdalena, Petersen Jörg, Böker Klaus H W, Grigorian Natalia, Link Ralph, Naumann Uwe, John Christine, Lueth Stefan, Malfertheiner Peter, Manns Michael P, Wedemeyer Heiner, Sarrazin Christoph, Cornberg Markus

Abstract excerpt

BACKGROUND: SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN and Ribavirin (RBV)...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Biomarkers
Share to Follow-Up Studies
Share to Hepacivirus
Share to Hepatitis C, Chronic
Share to Interferons
Share to Interleukins
Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 26699619
DOI: 10.1371/journal.pone.0145622
PMCID: PMC4689517

Genes

IFNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting.PMID 26699619Read ↗

Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha.Semantic proximity Read ↗

IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection.Semantic proximity Read ↗

Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.Semantic proximity Read ↗

Association of IFNL3 and IFNL4 polymorphisms with hepatitis C virus infection in a population from southeastern Brazil.Semantic proximity Read ↗

Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection.Semantic proximity Read ↗

Can IFNL3 polymorphisms predict response to interferon/ribavirin treatment in hepatitis C patients with genotype 3?Semantic proximity Read ↗

IFNL3/4 genotype is associated with altered immune cell populations in peripheral blood in chronic hepatitis C infection.Semantic proximity Read ↗

Interferon Lambda-3 rs12979860 Variants and Response to Pegylated Interferon in Chronic Hepatitis-C Genotype-3.Semantic proximity Read ↗

Interferon lambda 4 genotypes and resistance-associated variants in patients infected with hepatitis C virus genotypes 1 and 3.Semantic proximity Read ↗

IL28B polymorphisms and clinical implications for hepatitis C virus infection in Uzbekistan.Semantic proximity Read ↗

The evaluation of interferon lambda 4 rs368234815 as a predictor factor in treated patients with chronic hepatitis C genotype 1a infection.Semantic proximity Read ↗

Interferon-λ3 polymorphisms in pegylated-interferon-α plus ribavirin therapy for genotype-2 chronic hepatitis C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.