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Article

Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent.

Genes and immunity - 1 Mar 2014

O'Connor K S, Parnell G, Patrick E, Ahlenstiel G, Suppiah V, van der Poorten D, Read S A, Leung R, Douglas M W, Yang J Y H, Stewart G J, Liddle C, George J, Booth D R

Abstract excerpt

The IFNL3 genotype predicts the clearance of hepatitis C virus (HCV), spontaneously and with interferon (IFN)-based therapy. The responder genotype is associated with lower expression of interferon stimulated genes (ISGs) in liver biopsies from chronic hepatitis C patients. However, ISGs represent many interacting molecular pathways, and we hypothesised that the IFNL3 genotype may produce a characteristic pattern...

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Identifiers

PMID: 24335707
DOI: 10.1038/gene.2013.66

Genes

IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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