Article
Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.
Development (Cambridge, England) - 15 Jun 2016
Mašek Jan, Machoň Ondřej, Kořínek Vladimír, Taketo M Mark, Kozmik Zbyněk
Abstract excerpt
The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/β-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of...
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