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Article

The alx gene family confers segmental identity to frontonasal cranial neural crest cells.

Nature communications - 18 Jun 2026

Mumme-Monheit Abigail, Mitchell Jennyfer M, Bailon-Zambrano Raisa, Wright Nadia, Neukirch Lindsey A, Keating Margaret K, Hopkins Colette A, Riemondy Kent, Gustafson Grace E, Moss Nicole D, Medeiros Daniel M, Nichols James T

Abstract excerpt

Cranial neural crest cells in the pharyngeal arches give rise to vertebrate head skeletal structures. Hox genes confer segmental identity to the different arches, and Hox mutations result in mirror-image homeotic duplications. Frontonasal cranial neural crest cells reside anterior to the first pharyngeal arch, give rise to the midface skeleton, and are not considered part of the segmental series. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42315835
DOI: 10.1038/s41467-026-74434-w
PMCID: PMC13433946

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