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Article

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.

Developmental biology - 15 Feb 2002

Tian E, Kimura Chiharu, Takeda Naoki, Aizawa Shinichi, Matsuo Isao

Abstract excerpt

Previous analysis employing chimeric and transgenic rescue experiments has suggested that Otx2 is required in the neuroectoderm for development of the forebrain region. In order to elucidate the precise role of Otx2 in forebrain development, we attempted to generate an allelic series of Otx2 mutations by Flp- and Cre-mediated recombination for the production of conditional knock-out mice. Unexpectedly, the...

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Identifiers

PMID: 11820816
DOI: 10.1006/dbio.2001.0531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.PMID 11820816Read ↗

Deletion of OTX2 in neural ectoderm delays anterior pituitary development.Semantic proximity Read ↗

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Mouse Otx2 functions in the formation and patterning of rostral head.Semantic proximity Read ↗

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.Semantic proximity Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Otx2 and HNF3beta genetically interact in anterior patterning.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

The caudal limit of Otx2 expression positions the isthmic organizer.Semantic proximity Read ↗

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