Article
High-specificity detection of rare alleles with Paired-End Low Error Sequencing (PELE-Seq).
BMC genomics - 14 Jun 2016
Preston Jessica L, Royall Ariel E, Randel Melissa A, Sikkink Kristin L, Phillips Patrick C, Johnson Eric A
Abstract excerpt
BACKGROUND: Polymorphic loci exist throughout the genomes of a population and provide the raw genetic material needed for a species to adapt to changes in the environment. The minor allele frequencies of rare Single Nucleotide Polymorphisms (SNPs) within a population have been difficult to track with Next-Generation Sequencing (NGS), due to the high error rate of standard methods such as Illumina sequencing....
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