Article
Whole-genome sequencing and variant discovery in C. elegans.
Nature methods - 1 Feb 2008
Hillier LaDeana W, Marth Gabor T, Quinlan Aaron R, Dooling David, Fewell Ginger, Barnett Derek, Fox Paul, Glasscock Jarret I, Hickenbotham Matthew, Huang Weichun, Magrini Vincent J, Richt Ryan J, Sander Sacha N, Stewart Donald A, Stromberg Michael, Tsung Eric F, Wylie Todd, Schedl Tim, Wilson Richard K, Mardis Elaine R
Abstract excerpt
Massively parallel sequencing instruments enable rapid and inexpensive DNA sequence data production. Because these instruments are new, their data require characterization with respect to accuracy and utility. To address this, we sequenced a Caernohabditis elegans N2 Bristol strain isolate using the Solexa Sequence Analyzer, and compared the reads to the reference genome to characterize the data and to evaluate...
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