Article
From next-generation resequencing reads to a high-quality variant data set.
Heredity - 1 Feb 2017
Pfeifer S P
Abstract excerpt
Sequencing has revolutionized biology by permitting the analysis of genomic variation at an unprecedented resolution. High-throughput sequencing is fast and inexpensive, making it accessible for a wide range of research topics. However, the produced data contain subtle but complex types of errors, biases and uncertainties that impose several statistical and computational challenges to the reliable detection of...
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