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A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors.

Frontiers in endocrinology - 1 Jan 2021

Miranda-Lora América Liliana, Vilchis-Gil Jenny, Juárez-Comboni Daniel B, Cruz Miguel, Klünder-Klünder Miguel

Abstract excerpt

Background: Type 2 diabetes (T2D) is a multifactorial disease caused by a complex interplay between environmental risk factors and genetic predisposition. To date, a total of 10 single nucleotide polymorphism (SNPs) have been associated with pediatric-onset T2D in Mexicans, with a small individual effect size. A genetic risk score (GRS) that combines these SNPs could serve as a predictor of the risk for...

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PMID: 33776940
DOI: 10.3389/fendo.2021.647864
PMCID: PMC7994893

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